Man holding an injection pen for diabetic

In recent years, the landscape of medical weight management has been significantly enriched by the introduction of injectable medications such as semaglutide and tirzepatide. These medications have been groundbreaking in their ability to help individuals achieve substantial weight loss, particularly when lifestyle changes alone do not yield the desired results. Understanding the differences between these medications and how they work can help you determine which might be the best fit for your weight loss journey.


Semaglutide, sold under the brand names such as Ozempic and Wegovy, is a glucagon-like peptide-1 (GLP-1) receptor agonist. This medication mimics the action of the hormone GLP-1 that your intestine secretes in response to food, which helps regulate insulin secretion and decreases glucagon levels. What makes semaglutide particularly effective is its ability to slow gastric emptying and suppress appetite, which leads to reduced calorie intake and significant weight loss. Semaglutide has been approved by the FDA not only for managing type 2 diabetes but also, in higher doses, for chronic weight management.


Tirzepatide, marketed as Mounjaro, represents a newer class of FDA-approved injectable weight loss medications.1 It is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist. This unique combination not only enhances the effects seen with GLP-1 alone but also leverages the insulinotropic and weight-lowering effects of GIP. Clinical studies have demonstrated that tirzepatide may lead to even greater weight loss compared to GLP-1 receptor agonists alone.2 This makes it a promising option for individuals who may not have achieved their desired weight loss goals with other medications.

Choosing the Right Medication for You

When considering these medications for weight loss, it’s essential to consult with a healthcare provider who can evaluate your individual health needs and medical history. 

Here are a few considerations to keep in mind:

Learn More About Weight Loss Injections

Semaglutide and tirzepatide are all powerful tools in the fight against obesity, each with unique characteristics that might make one more suitable than another depending on individual circumstances. By understanding these differences and discussing them with your healthcare provider, you can make an informed decision that aligns with your health goals and lifestyle preferences. Remember, these medications are most effective when combined with a sustained program of lifestyle modification, including diet and exercise.

If you’re ready to begin your weight loss journey, contact the providers at Before-N-After to discuss your options for weight loss management and see if medication is right for you. Your path to a healthier future starts here!

1FDA. FDA Approves New Medication for Chronic Weight Management. Available: Accessed May 9, 2024.

2Patient Preference and Adherence. The Body weight Reducing Effects of Tirzepatide in People with and without Type 2 Diabetes: A Review on Efficacy and Adverse Effects. Available: Accessed May 9, 2024. Tirzepatide vs semaglutide: How do they compare? Available: Accessed May 21, 2024.

4Cleveland Clinic. GLP-1 Agonists. Available: Accessed May 9, 2024.